The research led by Dr. Vani Janakiraman, Assistant Professor, Department of Biotechnology, Dr. Bhupat, and Dr. Jyoti Mehta School of Biosciences, IIT Madras revealed that the attack by Delta Plus, Gamma, Zeta, Mink, and Omicron variants can be dealt with by vaccine-induced T-cell responses.

The researchers claimed that the currently available spike protein vaccinations are efficacious against circulating variants of Coronavirus despite the compromised neutralizing antibody responses. The efficacy of different forms of spike protein-based vaccines depends on whether they can trigger the antibody response and the T cell response.

Dr. Janakiraman stated that the efficacy against multiple variants of SARS-CoV-2 variants can be assessed by first analyzing the epitope sequences of various variants for mutations. followed by whether they can effectively trigger T-cells induced in the immunization process. She added that the vaccines can be considered effective against the variants if there are fewer mutated epitopes in their spike proteins.